2 English control compound phenylpropanolamine hydrochloride, Contac [Xiangya Medical Dictionary]
3 Overview Yupingfeng oral liquid is a Chinese patent medicine [1]. See People's Republic of China (PRC) Pharmacopoeia (2000 edition). That is, Yupingfeng Powder [1] is an oral liquid. Each containing 10ml, the oral dosage is 10ml twice a day [1]. People's Republic of China (PRC) Pharmacopoeia (version 20 10) also records the pharmacopoeia standard of this Chinese patent medicine.
Yupingfeng Powder is the name of prescription, which comes from the prescription cited in Fang Yi Lei Ju [2].
4. Saposhnikovia divaricata, Astragalus membranaceus (baked with honey) and Atractylodes macrocephala each [2].
5. The preparation method is coarse powder [2].
6. Usage and dosage of Yupingfeng oral liquid: Take San Qian, add one jujube, decoct in water, and take it while it is hot after meals [2].
Indications: benefiting qi, consolidating exterior and stopping sweating [2]. Treat those patients with qi deficiency who are prone to catch a cold and sweat because of unclear principle [2]
8 Fang Jie takes Astragalus as the monarch, benefiting qi and consolidating the exterior; I use Atractylodes macrocephala to strengthen the spleen and help Astragalus strengthen the body. With the help of preventing wind and expelling wind, it can not only prevent Astragalus membranaceus and Atractylodes macrocephala from converging evil spirits, but also help the qi supplemented by surgery to circulate all over the muscle surface [2]. When Astragalus membranaceus protects against wind, it consolidates the exterior and leaves no evil; If you keep the wind away, you will get Astragalus membranaceus, and evil spirits will not hurt you [2]. In fact, there is dispersion in supplement, and dispersion contains the meaning of supplement [2]. Enriching Wei-qi can not only resist exogenous pathogens, but also protect body fluids [2].
Experimental study on pharmacological action: this prescription has a two-way regulation effect on the immune response of the body [2].
10 Pharmacopoeia Standard of Yupingfeng Oral Liquid 10. 1 Name Yupingfeng Oral Liquid
Yupingfeng oral liquid
10.2 prescription: 600g of Radix Astragali, 200g of Radix Saposhnikoviae and 200g of Atractylodis Macrocephalae (fried).
10.3 Prepare the above three medicinal materials, break up Radix Saposhnikoviae, extract volatile oil, and collect the distilled water solution in another container; Decocting the residue and the rest Radix Astragali with water twice, the first time is 65438 0.5 hours, and the second time is 65438 0 hours. Mixing decoctions, filtering, concentrating the filtrate to an appropriate amount, adding an appropriate amount of ethanol for precipitation, recovering ethanol from the supernatant under reduced pressure, adding water, uniformly stirring, standing, collecting the supernatant, filtering, and concentrating the filtrate. Take 400g of sucrose and make syrup, mix with the above liquid medicine, then add volatile oil and distilled water solution, adjust the total amount to 1000ml, stir evenly, filter, fill and sterilize.
10.4 characteristics this product is a reddish-brown to brownish-brown liquid; Its taste is sweet, slightly bitter and astringent.
10.5 Identification (1) Take this product 10ml, shake and extract it with water-saturated n-butanol for three times, 20ml each time, combine n-butanol solutions, and wash them with ammonia test solution for three times, 20ml each time, discard the ammonia solution, evaporate the n-butanol solution, and add methanol 1ml to dissolve the residue, and use it as a solvent. Another astragaloside IV reference substance was added with methanol to prepare a solution containing 65438±0mg per 65438±0ml as the reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), 2 ~ 4 μ l of the above two solutions were absorbed, respectively, on the same silica gel G thin-layer plate, and the chloroform-methanol-water (13: 7: 2) 10℃ lower layer solution was used as the developing agent, and then unfolded and taken out. In the chromatogram of the test sample, spots with the same color appear in the position corresponding to the chromatogram of the reference sample; Under the ultraviolet lamp (365nm), fluorescent spots of the same color appeared.
(2) Take 20ml of this product, shake it with petroleum ether (30 ~ 60℃) and extract it twice, 25ml each time, combine the extractive solutions, evaporate to dryness, and dissolve the residue with 1ml methanol as the test solution. Another 2g of Atractylodes macrocephala control medicinal material is added with 50ml of water, decocted for 30min, cooled, filtered, and the filtrate is prepared into a control medicinal material solution by the same method. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), absorb 5μl of the above two solutions, respectively spot them on the same silica gel G thin-layer plate, unfold them with cyclohexane-ethyl acetate (7: 3) as the developing agent, take them out, dry them, and spray them with 5% p-dimethylaminobenzaldehyde 10% sulfuric acid ethanol solution. In the chromatogram of the test sample, spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials; Under the ultraviolet lamp (365nm), fluorescent spots of the same color appeared.
(3) Take 65438±0ml of this product, add methanol to 65438 00 ml, shake well, centrifuge, and take the supernatant as the test solution. In addition, 5O methyl visamiodarone reference substance was taken, and methanol was added to make a solution containing 60μg per kloc-0/ml as the reference substance solution. According to the test of high performance liquid chromatography (Appendix D of Pharmacopoeia I, 20 10), octadecylsilane bonded silica gel was used as filler. Using methanol-water (35∶65) as mobile phase; The detection wavelength is 254 nm. Suck 10μl control solution and test solution respectively, and inject them into liquid chromatograph. In the chromatogram of the test sample, the chromatographic peak with the same retention time as that of the control sample should be presented.
The relative density of 10.6 inspection 10.6. 1 shall not be lower than 1. 16 (Appendix VII A of Pharmacopoeia 20 10).
10.6.2 the ph value should be 4.0 ~ 5.5 (appendix ⅶ g of pharmacopoeia I of 2010 edition).
10.6.3 others shall comply with the relevant provisions under the mixture (Appendix I J of Pharmacopoeia I of 20 10).
The content of 10.7 was determined by high performance liquid chromatography (Pharmacopoeia 20 10, Appendix 6? D) determination.
10.7. 1 chromatographic conditions and system applicability test: octadecylsilane bonded silica gel is used as filler; Acetonitrile-water (35: 65) was used as the mobile phase; Detected by evaporative light scattering detector. According to the peak calculation of astragaloside IV, the theoretical plate number should be not less than 3000.
10.7.2 preparation of reference solution take appropriate amount of astragaloside iv reference substance, weigh it accurately, and add methanol to make a solution containing 0.4mg per 1ml.
10.7.3 preparation of test solution accurately measure 20ml of this product, shake and extract it with water-saturated n-butanol for 5 times, 25ml each time, combine the n-butanol extract, wash it with ammonia test solution for 3 times, 20ml each time, recover the solvent in the n-butanol extract to dryness, dissolve the residue with methanol, transfer it to a 10ml volumetric flask, add methanol to the scale, and shake well.
10.7.4 determination method accurately absorbs 5μl and 20μl of control solution and 10μl of test solution respectively, injects them into liquid chromatograph, determines them, and calculates them by two-point logarithmic equation of external standard method.
Every 1ml of this product contains astragaloside IV (C4 1H68O 14), which shall not be less than 0. 12mg.
10.8 function is mainly used to replenish qi, consolidate exterior and stop sweating. It is suitable for patients with different exterior deficiency, spontaneous sweating and aversion to wind, pale face or physical weakness who are vulnerable to wind evil.
10.9 Administration and dosage taken orally. 10ml once, three times a day.
10. 10 specifications per carton 10ml.
10. 1 1 Store in a cool place.
10. 12 Edition People's Republic of China (PRC) Pharmacopoeia 20 10 Edition
1 1 Yupingfeng oral liquid description 1 1. 1 drug type Chinese traditional medicine
1 1.2 drug name Yupingfeng oral liquid
1 1.3 Chinese phonetic alphabet of drugs 1 1.4 English name of drugs 1 1.5 components 1 1.6 characters1/kloc. It is used for patients with weak body surface, spontaneous sweating and aversion to wind, pale face, or weak body and vulnerable to wind evil.
1 1.9 specifications per carton10ml.
Usage and dosage of Yupingfeng oral liquid 1 1. 10. 10 ml once, three times a day.
11.11contraindications1.12 Adverse reactions1.13 Precautions. Avoid indigestion.
2. Patients with cold and fever should not take it.
3. People suffering from serious chronic diseases such as hypertension, heart disease, liver disease, diabetes and kidney disease should take it under the guidance of a doctor.
Children, pregnant women and lactating women should take it under the guidance of a doctor.
5. After taking the medicine for 4 weeks, the symptoms have not eased, so I have to go to the hospital.
6. It is forbidden for those who are allergic to this product, and should be used with caution for those who are allergic.
7. It is forbidden to use this product when its characteristics change.
8. Children must use it under the supervision of adults.
9. Please keep this product out of the reach of children.
10. If you are using other drugs, please consult a doctor or pharmacist before using this product.
1 1. 14 If used with other drugs, drug interactions may occur. Please consult a doctor or pharmacist for details.
1 1. 15 pharmacological action of Yupingfeng oral liquid 1 1. 16 Remarks