As a professional motorcycle repairman, let me tell you,
1\Compared with air-cooled machines, water-cooled machines are more suitable for long-distance running ,,Air-cooled ones are more suitable for short distances, because if you want to run long distances, the engine must dissipate heat well. In this regard, water-cooled machines have an advantage.
2\ Water-cooled ones can run continuously. for how long? This problem cannot be explained by data. It is interrelated with your usual car maintenance, the road surface and weather you choose.
But for water-cooled ones, you must be careful not to overuse them. I burned myself.