Speaking of Naruto, I think everyone should know it, because it is a very classic anime. Even if you have not seen it, you must have heard of it. Orochimaru can say He is my favorite character in Naruto. He is also a very popular character. Orochimaru is very strong and has super vitality. It can be said that no one can kill him, but there are 3 A ninja can actually kill Orochimaru.
The first is Uzumaki Nagato. Uzumaki Nagato is very powerful. He is a collection of Six Paths of Payne. Compared with Orochimaru, he is like an adult and an elementary school student. There is no comparison at all. Uzumaki Nagato can kill Orochimaru instantly. Anyone who has watched Naruto knows that Orochimaru can use the corpse to reincarnate, and Nagato is good at devouring souls, so Uzumaki Nagato wants to kill Orochimaru. The pill is actually very simple.
Second, there is Namikaze Minato. Namikaze Minato is the Fourth Hokage. His combat power is actually not as high as Nagato, but he has the wisdom of the Fourth Hokage, so he is ranked higher than Nagato. The gate is one level higher, and the ninjutsu Orochimaru is most afraid of is the sealing of zombies, and the Fourth Hokage can fully withstand the backlash caused by the sealing of corpses, so Minato Namikaze wants to kill Orochimaru. It's also a very simple thing.
Third, there is Naruto. Naruto's combat power should be the strongest in the ninja world, and he is also the Seventh Hokage. Naruto is best at using illusions. As long as he uses one on Orochimaru The illusion of time can cause Orochimaru's spirit to collapse. The spiritual death of a person means the death of the soul, and Orochimaru cannot use the corpse to reincarnate. The above are the 3 ninjas who can kill Orochimaru.