What drugs are really effective in treating gout?

Colchicine should be the first choice for acute gout and has selective anti-inflammatory and analgesic effects on acute gouty arthritis. Although phenylbutazone and indomethacin do not have the above effects, they also have good effects on relieving the symptoms of gouty arthritis, so they can be selected. Allopurinol can reduce the biosynthesis of uric acid; Probenecid and bensulfuron-methyl can promote uric acid excretion and are generally used in patients with chronic gout. Gout is a metabolic disease. In addition to the above medication, we should also pay attention to adjusting diet, that is, don't eat high-purity food, such as heart, liver, kidney, brain, sardines, yeast and so on. Strictly abstain from drinking, drink more water, and urinate more than 2000 ml a day. Drugs that inhibit uric acid excretion, such as salicylic acid, acetylpyrazine, thiazide diuretics, furosemide and uric acid, are strictly prohibited. Colchicine: Colchicine is an alkaloid extracted from colchicine bulbs and seeds. It can inhibit the increase of white blood cells caused by urate crystallization and interfere with the chemotaxis of white blood cells, so it has anti-inflammatory and analgesic effects. 2. Non-steroidal anti-inflammatory drugs: Non-steroidal anti-inflammatory drugs have the same effect on gouty arthritis as colchicine. However, due to the toxic side effects of colchicine, many gout patients prefer to use non-steroidal anti-inflammatory drugs. Non-steroidal anti-inflammatory drugs can relieve inflammation symptoms such as redness, swelling, heat and pain of joints, improve the functions of some muscles, bones and joints, and effectively prevent edema. At present, the commonly used non-steroidal anti-inflammatory drugs in clinic mainly include indomethacin, diclofenac, ibuprofen and rofecoxib. 3. Glucocorticoid drugs: Glucocorticoid drugs can inhibit non-infectious inflammation, reduce joint congestion and edema, and have the characteristics of rapid onset. However, because the symptoms of gout patients are easy to recur after stopping taking glucocorticoid drugs, these drugs are only suitable for gout patients with very serious individual symptoms, recurrent attacks or ineffective treatment with the above drugs. At present, glucocorticoid drugs commonly used in clinic mainly include prednisone, hydrocortisone and prednisolone. 4. Uric acid excretion drugs: Uric acid excretion drugs mainly include salicylic acid drugs, probenecid, sulfamethadone and benzbromarone. These drugs can prevent renal tubules from reabsorbing uric acid, increase uric acid excretion, and thus reduce the level of blood uric acid in human body.