In 1999, Ji Jinxi participated in the filming of Zhao Chengbin's MV "A Third-rate Movie" and made her official debut. In 2000, he starred in the SBS TV series "Juliet's Boyfriend". In 2001, he starred in the TV series "Four Doctor Sisters", playing the role of Han Tae-seok. In 2003, he filmed the MBC costume drama "Dae Jang Geum" and played the leading role Min Jung Ho. From the end of 2003 to the beginning of 2004, "Dae Jang Geum" was broadcast in South Korea and won the 2004 Korean ratings championship with an average ratings of 47.8%. In 2004, he participated in the SBS TV series "Million Bride", playing the role of Park Moo-yeol. Ji Jin-hee won the 2004 SBS Drama Awards TV Drama Special Actor Award and the Best TV Couple Award (with Kim Hyun-joo) for this drama.
In 2005, he co-starred with Moon So-ri in the movie "The Secret Charm of the Female Professor", in which he played a cartoonist with a bad temper and violent tendencies; in the same year, Ji Jin-hee participated in the SBS TV series In "Spring Day", Ji Jin-hee plays Go Eun-ho, an outstanding doctor who works in his father's hospital.
; In addition, he also sang the episode "That Sadness, That Pain" of this TV series. This year he also starred in the Sino-Korean co-production "The Hundred Bride" and the movie "If Love" directed by Chen Kexin, and made a cameo in the Hong Kong movie "Springfield Flowers Alumni Reunion" as a character without a single line.
In 2007, he participated in the movie "The Ancient Courtyard" and played the role of Wu Xianyu. In 2008, she co-starred with Son Ye-jin in the TV series "Spotlight", playing the role of Oh Tae-seok, an outstanding reporter from the Social News Department with excellent on-site experience. In 2009, he participated in the KBS TV series "The Man Who Cannot Marry"; for his role as Cho Jae Hee, he won the 2009 KBS Drama Awards for the Best Actor in a Miniseries.
In 2010, he played Sukjong in the MBC TV series "Dong Yi" and won the 2010 MBC Drama Awards Best Acting Award for this drama. In 2012, he participated in the SBS TV series "The Big Maple Tree", which tells the story of the powerful Feng Shui master who helped Li Chenggui establish North Korea at the end of the declining Goryeo Dynasty; Ji Jinxi played the role of the North Korean Taizu Li Chenggui.
On March 28, 2014, the Sino-Korean love movie "I Love You Most on the Road" co-starring Ji Jinxi, Huang Shengyi, and Wen Zhang was released; in the play, Ji Jinxi plays a man who flies to China to seek emotional healing. South Korean doctor Joo Hwan.
On June 13, 2014, the romance film "Bad Sister: Breaking Up the Marriage Alliance" jointly produced by Donghai Film Group, REG Communications, etc. was launched in Shanghai. Korean director Kim Tae-kyun and starring Chen Yihan and Ji Jinxi turn up. The film started filming in Busan on June 18, 2014. After nearly two months of filming, it was officially completed on August 6. The film was released on November 28, 2014.
On February 16, 2015, the KBS monthly drama "Blood" starring Ji Jin Hee was launched, cooperating with Ahn Jae Hyun and Goo Hye Sun to stage the story of a vampire doctor.
On March 9, 2015, the movie "Equator" held a press conference in Beijing. It was directed by the "Chill" director duo Liang Lemin and Lu Jianqing, and starred Jacky Cheung, Nick Cheung, Shawn Yue, Wang Xueqi, Janice Man, Chi Jin-hee, Cui Siyuan, Yin Starring Jin Yi, Gu Meihua, Feng Wenjuan and Zhang Zhen, it tells the story of Chinese and Korean military and police elites joining forces to resolve the crisis of super nuclear weapons. Ji Jinxi plays the role of a Korean weapons expert. The movie is scheduled to be released on April 30, 2015.
On August 22, 2015, the special weekend drama "I Got a Lover", cooperating with Kim Hyun-joo, was broadcast on SBS.
The movie "Sorry I Love You Thank You" with Kim Sung-jun and Sung Yu-ri is scheduled to be released on October 29, 2015.