What are the contents of the two cardinal principles and six changes of traditional Chinese medicine? Who proposed it?

It was put forward by Zhang Jiebin. Zhang Jiebin Jingyue. At first, he admired Zhu Zhenheng's knowledge, and later he became more and more experienced. He believed in Zhang He's theory of invigorating qi and strengthening spleen, and advocated that "Yang always exists, while Yin is often insufficient". In clinical practice, he often used the prescription of stabilizing and reinforcing, and became one of the representatives of the school of warming and reinforcing, which had a great influence on later medicine.

Zhang Jingyue is called "Yin and Yang" and "Six Changes" in "The Complete Book of the Pure Moon and the Record of Nakagawa", that is, "Two Lessons and Six Changes", and he unified the six changes with two lessons. He said, "Yin and Yang are bright, then the exterior and interior are positive, the excess and the deficiency are positive, the cold and the heat are positive, and the six become bright, and the diseases in the world cannot be done." It can be clearly seen that he regards two kinds of six changes as a dialectical program. Therefore, taking exterior, interior, cold, heat, deficiency, reality and yin and yang as the dialectical program was actually formed in the Ming Dynasty.