Yes, after excluding the possibility of heart failure, nephropathy, liver cirrhosis and venous embolism, we judged that it might be edema caused by amlodipine, so we suggested that uncle stop using amlodipine and switch to valsartan to lower blood pressure.
In fact, the mechanism of leg edema caused by amlodipine is related to its mechanism of action. It can reduce blood pressure by dilating arterioles, but it will not dilate venules, which will increase the pressure of capillary circulation, thus increasing the permeability of capillaries, making fluid extravasate to surrounding tissues, leading to peripheral edema. Besides amlodipine, dihydropyridine calcium channel blockers (CCB) such as nifedipine and felodipine can cause peripheral edema, especially in the ankle.
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Studies have shown that the peripheral edema caused by amlodipine and nifedipine dihydropyridine calcium channel blockers may indeed be dose-dependent, and the risk of edema in large doses is 2-3 times that in small doses.
Not sure yet.
However, studies have shown that the risk of peripheral edema of the new generation of dihydropyridine calcium channel blockers such as levoamlodipine, lacidipine and cilnidipine is lower than that of traditional drugs such as nifedipine and amlodipine, but further research is needed.
The following measures can be taken:
1. Amlodipine is reduced or stopped;
2. Changing amlodipine or adding renin-angiotensin system (RAS) inhibitors, whether ACEI (angiotensin converting enzyme inhibitors, such as captopril and perindopril) or ARB (angiotensin receptor blockers, such as valsartan and irbesartan), can significantly reduce the incidence and severity of edema caused by calcium channel blockers, which may be because ACEI/ARB can reduce capillary pressure by dilating veins.
3. Amlodipine can also be changed to non-dihydropyridine calcium channel blockers, such as verapamil and diltiazem. , thus reducing the risk of edema.
This is a list of drugs that may cause edema. If a patient who is taking the following drugs has edema, it is recommended to consult your doctor or pharmacist to determine whether it is a side effect caused by the drug.
Of course, the above drugs cannot cover all drugs that may cause edema. If your doctor suspects that edema is caused by a drug after excluding disease factors, you can consult your pharmacist to help you evaluate the correlation between adverse reactions and drugs.
I am a pharmacist with 1 1 years of clinical medication management experience, and I am committed to rational drug use, adverse reactions and interaction monitoring. If you find this article useful, you can click Like as encouragement or forward it to friends in need. Welcome to pay attention and leave a message. * * * Let's talk about healthy living and medication.
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