Ge Hong was a famous doctor and mediator of preventive medicine in the Eastern Jin Dynasty. He is the author of The Elbow, which recorded some infectious diseases, such as smallpox and scrub typhus, as well as their diagnosis and treatment for the first time. Tinea in Heaven is the earliest record of smallpox in the world. He is also experienced in alchemy. The inner chapter of the alchemist Bao Puzi specifically tells the chemical knowledge of refining gold and silver pills, and also introduces many material properties and material changes. For example, "Red mercuric sulfide (red mercuric sulfide) decomposes red mercuric sulfide (red mercuric sulfide) by heating. Adding sulfur to mercury can generate black mercuric sulfide and then become red mercuric sulfide. The reversibility of chemical reaction is described. Another example is "Zeng Qing painted iron, iron red as copper", which describes the reaction of iron replacing copper, and so on. " The Axis of Ge Zhichuan's Migration was painted by Meng, and the Map of Ge Xian's Spitting Fire in the Palace Museum was painted by Xu, which is in the Shanghai Museum.