Functions of Notopterygium incisum
Used for exogenous cold, aversion to cold and fever, headache and body pain. This product has a strong effect of dispelling cold and relieving pain. It is often used with Radix Saposhnikoviae, Radix Angelicae Dahuricae and Asari, such as Jiuwei Notopterygii Decoction.
It is used for joint pain, shoulder and back pain caused by pathogenic wind, cold and dampness, especially for upper body pain. This product can dispel wind and warm, dispel cold and relieve pain. It is often combined with Fangfeng, such as Juanbi Decoction.
Used for impotence, nocturnal emission, enuresis, frequent micturition, cold pain in waist and knees, asthma due to kidney deficiency, and nocturnal diarrhea; Topical treatment for vitiligo and alopecia areata. Relieve exterior syndrome, dispel cold, dispel wind and overcome dampness, and relieve pain.
Relieve exterior and dispel cold.
Indications: cold, aversion to cold, no sweating, headache and body pain.
Anti-allergic effect
It can inhibit the delayed hypersensitivity induced by 2,4-dinitrochlorobenzene (DNCB) in mice.
Anti-arrhythmia effect.
The water-soluble part can obviously shorten the duration of arrhythmia in rabbits and delay the occurrence of arrhythmia induced by aconitine in mice. This effect increased with the increase of dose, but it weakened when the dose increased to 12g/kg.
Anti-myocardial ischemia effect.
Its volatile oil can antagonize acute myocardial ischemia caused by pituitrin. In addition, the volatile oil of Notopterygium Rhizoma can significantly increase the nutritional blood flow of myocardium, thus improving myocardial ischemia.
Antishock effect.
It is effective to take small doses for many times, but large doses can not improve the anti-shock ability of animals.
Antithrombotic, antioxidant.
Taking notopterygium root can prevent thrombosis. Has anti-lipid peroxidation effect.
Other functions.
Notopterygium root also has antiepileptic effect; It also has certain inhibitory effect on cervical cells.
pharmacological action
(1) antipyretic and analgesic.
Its volatile oil can obviously reduce the body temperature of experimental fever rats and has obvious analgesic effect. The water extract of Notopterygium Shi Sheng decoction has obvious antipyretic and analgesic effects on fever in rabbits.
(2) Anti-inflammatory.
Its volatile oil can obviously inhibit the swelling of paw of rats and auricle of mice by gavage, and obviously reduce the capillary permeability of abdominal cavity and inflammatory exudation. Qianghuo Shi Sheng Decoction has a strong anti-inflammatory effect. Its water extract can obviously inhibit the capillary permeability of abdominal cavity, and obviously inhibit inflammatory reactions such as paw swelling in rats and auricle swelling in mice. It has obvious inhibitory effect on early joint swelling of adjuvant rats.
(3) immunity.
It has a significant inhibitory effect on delayed hypersensitivity; It can obviously enhance the immune function of rat arthritis model, promote the phagocytosis of whole blood leukocytes in rats and improve the transformation rate of peripheral blood lymphocytes.
(4) Anti-arrhythmia and protection of myocardial ischemia.
Its water extract can delay the occurrence of arrhythmia caused by aconitine in mice and obviously shorten the duration of arrhythmia. The volatile oil of Notopterygium root can antagonize acute myocardial ischemia caused by pituitrin. This may be the result of dilating coronary artery and increasing coronary blood flow. The volatile oil of Notopterygium incisum can obviously increase myocardial nutrient blood flow, thus improving myocardial ischemia.
(5) others.
Viscosity reduction: its water extract can obviously reduce the blood viscosity of rats.
Antibacterial: The volatile oil of Notopterygium incisum has different antibacterial effects on many bacteria in vitro.
Efficacy of notopterygium root
The taste is hard and warm.
"Theory of Medicinal Properties": "Bitter and pungent, non-toxic."
The origin of medicine: The Notes on Indications says that it is warm in nature and pungent in taste. "
Herbal soup: "the gas is slightly warm, the taste is bitter and sweet, and it is flat."
Meridian enters bladder and kidney.
Pearl sac: "bladder meridian of foot sun." "Hands, sun, small intestine."
Herbal soup: "Foot Sun and Jueyin Meridian."
Materia Medica: "The hands and feet are full of the sun, and the feet are full of Yin Jue Yin Meridian."
Function: Dispelling exterior cold, expelling wind and removing dampness, and benefiting joints. Treat common cold, headache, anhidrosis, arthralgia due to wind-cold-dampness, stiff neck, joint pain, geomantic edema and carbuncle.
"On the Essence of Medicine": "Treating thief wind, losing voice and silence, itchy blood rash, paralysis of hands and feet, crooked mouth and face, stubborn whole body."
"Rihuazi Materia Medica": "Treating wind and qi, muscle contracture, limb obstruction, head rotation and red eyes pain, cold and damp, five strains and seven injuries, deficiency and cold, joint pain, benefiting five internal organs."
Pearl Capsule: "When the sun has a headache, it can warm the gallbladder and remove the pain of all joints."
"The principle of quality meeting": "The main body is full of pain, and the muscles are full of eight pathogenic factors. In addition to old and new rheumatism, it can drive away carrion, gangrene and sores."
Compendium of Materia Medica: "Purging liver qi, searching liver wind, treating rheumatism, headache due to meridian (Yang), disease due to du meridian, stiff spine and syncope, stroke without words, head spinning and red eyes."
"Medical Mirror": "Cure evil, close cold, strong heat without sweat."
Qianghuofang
Treatment of cold, fever and tonsillitis: Notopterygium is four to five yuan, Radix Isatidis and Dandelion are one or two each. Decoct with water, one dose per day, and take it twice. (Longhua Hospital affiliated to Shanghai College of Traditional Chinese Medicine)
Treating sun typhoid without sweating: Notopterygium, Radix Angelicae Pubescentis, Schizonepeta, Radix Saposhnikoviae, Magnolia Officinalis and Glycyrrhiza uralensis. Decoct. ("medical grade" Notopterygium decoction)
Clearing teeth and dispelling cold: Notopterygium Rhizoma, Radix Saposhnikoviae, Rhizoma Atractylodis, Asari, Rhizoma Chuanxiong, Radix Angelicae Dahuricae, Radix Rehmanniae, Scutellariae Radix and Glycyrrhrizae Radix. Take it in water. If you sweat and take it while it is hot, throw it in soup and porridge. If you sweat and take it warm, don't use soup. (Zhang Jiuwei Qianghuo Decoction)
Treatment of headache in Taiyang Meridian: two points of Fangfeng, three points of Notopterygium and two points of Hongdou. Finally, the nose is twitching. ("Yu Jiwei Yi")
Treatment of cold attacks the brain, brain pain, cold hands and feet, cold nose and mouth: Notopterygium root is one yuan, aconite root, dried ginger are five points each, and roasted licorice root is eight points. Decoct with water. (Notopterygium and Chuanwu Decoction in medical understanding)
Treating rheumatism, body aches, pain or body swelling: Notopterygium Rhizoma (removing reed), Radix Aconiti Lateralis Preparata (processing and peeling umbilical cord), Atractylodis Rhizoma, and Glycyrrhrizae Radix (baking). Four yuan each, one and a half lamps of water, five slices of ginger, fried to seven cents, and served warm at any time. ("Fang Jisheng" and "Fu Qiang Tang")
The treatment of shoulder and back pain can't be recalled. My back hurts badly, and my waist seems to be broken. It seems that the items that have been pulled out are: Notopterygium Rhizoma and Radix Angelicae Pubescentis, each for one yuan; Rhizoma Ligustici, Radix Saposhnikoviae, Radix Glycyrrhizae (parched) and Rhizoma Chuanxiong each have five points, and Fructus Viticis Chinensis has three points. Make one, two cups of water, stir-fry to one cup, remove the residue, take it at high temperature, and eat it before eating. (Syndrome Differentiation of Internal and External Injuries: Qianghuo Shi Sheng Decoction)
Treatment of tonsillitis: Notopterygium incisum 12- 15g, Radix Isatidis and Herba Taraxaci each 30g, decocted in water, daily 1 dose, taken twice. (Dictionary of Traditional Chinese Medicine, page 1 173) 9 Treatment of premature beats: "Maggie" is an extract preparation of Notopterygium Rhizoma (provided by Chinese Academy of Traditional Chinese Medicine and produced by Guangzhou Xingqun Pharmaceutical Factory, 1 ml pulse liquid is equivalent to 1 g crude drug of Notopterygium Rhizoma), and the daily dosage is 60-/kloc-0. (Chinese Journal of Internal Medicine,1985; 27(7):452)
Side effects of notopterygium root
(A) traditional literature
Theory of medicinal properties: nontoxic.
Modern research
Chemical composition: This product contains volatile oil, β-sitosterol, coumarin, phenolic compounds, carotene, parsley B, organic acids and alkaloids.
Pharmacological effects: Notopterygium injection has analgesic and antipyretic effects, and has inhibitory effects on skin fungi and Brucella. The water-soluble fraction of Notopterygium root has anti-experimental arrhythmia effect. The volatile oil also has anti-inflammatory, analgesic and antipyretic effects, which can resist myocardial ischemia caused by pituitrin and increase myocardial nutritional blood flow. It can inhibit delayed allergic reaction in mice.
(3) Toxicological test
LD50: The LD50 of Notopterygium Rhizoma volatile oil was 6.64g±0.87ml/kg.
Toxic reaction:
The maximum tolerance of water extract of Notopterygium incisum to mice was 40g (crude drug) /kg, and the maximum tolerance of intraperitoneal injection was L2.5g/kg.
The maximum tolerance dose of Qianghuo Shi Sheng Decoction to mice is 62.4g (crude drug) /kg, which is equivalent to 133 times of the clinical dosage.
In the long-term toxicity test of Notopterygium Shi Sheng Decoction, rats were given 46.80 g/kg, 23.40 g/kg and 2.34 g/kg by gavage (equivalent to 100, 50 and 5 times of clinical dosage). After 4 weeks of continuous administration and 2 weeks of drug withdrawal, there were no abnormal changes in growth and development, blood routine, liver and kidney function and important organs of rats in each dose group.
The above shows that Notopterygium Notopterygium and Notopterygium Notopterygium Shi Sheng Decoction have little toxicity and great safety.
(4) Clinical observation
Notopterygium root is nontoxic. There is no uncomfortable reaction after the conventional dose of water decoction. Long-term use or large dose (below 30g) decoction has no obvious side effects.
Decoct 30 grams of water each time. Generally, there is no obvious uncomfortable reaction to arthritis patients, and some patients have the reaction of getting angry and sweating. For patients with cold and fever, sweating can reduce fever, but it does not increase internal heat; For people who were originally suffering from excessive internal heat and spontaneous sweating due to physical weakness, if they were decocted with 12g water, there would be an increase in excessive internal heat and sweating. This is what Chinese medicine says: if you are sick, you will get sick. The truth that all diseases do not harm healthy qi.
Qiangqiang practice daquan
Qianghuo Fangfeng decoction
The medicine consists of Notopterygium Rhizoma (removing reed head) 3, Radix Saposhnikoviae (removing fork) 4, Radix Platycodi 3, Radix Bupleuri (removing seedling) 1, Herba Patriniae 3, Cortex Cinnamomi (removing coarse skin) 1, Radix et Rhizoma Rhei (filing) 2, and antelope horn (mashing) 1.
Source of Prescription Science: General Records of Holy Sites (volume 16 1).
This prescription is mainly used to treat postpartum abdominal stiffness, fullness in both sides, cold hands and feet, upset and enthusiastic, vomiting after drinking, joint cramps and stroke.
The preparation method is coarse powder.
Usage and dosage: Take 5 Bi Yuan, 2 cups of water each time, and fry to 1 cup, except me, and take it on an empty stomach, and then take it every time.
Qiangqiang Atractylodes Decoction
The medicine is prepared from 5 parts of Radix Glycyrrhizae Preparata, 5 parts of Cortex Phellodendri, 5 parts of Fructus Amomi Rotundus, 5 parts of Radix Glycyrrhizae, 5 parts of Radix Puerariae, 6 parts of Pericarpium Citri Tangerinae, 7.5 parts of Radix Bupleuri, Cimicifuga rhizome 1 yuan, Radix Angelicae Pubescentis 1 yuan, Fructus Amomi 1 yuan, Rhizoma Atractylodis 1 yuan and Radix Saposhnikoviae/kloc.
The prescription comes from Shi Lan's Secret Collection.
This prescription is mainly used to treat weakness and heaviness of feet and knees.
Usage and dosage in the mouth (parent). Divide it into 2 parts, 2 cups of water, fry it to 1 cup, and take it hollow.
Qianghuo Chu Shi decoction
Source: Medical Prescription Set.
Notopterygium Shi Sheng decoction is composed of Radix Angelicae Pubescentis, Fructus Viticis, Rhizoma Chuanxiong and Radix Glycyrrhizae, and Rhizoma Cimicifugae and Rhizoma Atractylodis are added.
Indications: rheumatism, mutual beat and general pain.
Notopterygium monkshood decoction
Prescription Ephedra 0.9g (removing roots and joints), Radix Aconiti Lateralis Preparata 0.9g, Notopterygii Rhizoma/kloc-0.5g, Rhizoma Atractylodis/kloc-0.5g, Radix Saposhnikoviae 0.6g, Radix Astragali 3g, Radix Glycyrrhizae, Rhizoma Cimicifugae 0.6g, Radix Angelicae Dahuricae, Bombyx Batryticatus and Cortex Phellodendri 0.9g each.
The main function is to treat the cold in winter and moon invading the brain, and brain pain and toothache are also called brain wind.
Administration and dosage: one dose. With 300ml of water, fry until150ml, take me out and take it warm after eating.
Cold and cough, 0.9 grams of gavage.
Excerpted from "Dongyuan Trial Prescription", Volume 5
Notopterygium wine
Source "Taiping Sheng Huifang"
The formula is one and a half parts of Notopterygium, one or two parts of Saposhnikovia divaricata (reed head removed) and one part of black beans.
In the method of making medicine, the first two flavors are mashed into powder with raw Luo, and five liters of good wine are used for one night.
It is mainly used for treating apoplexy, spasm, mouth opening, limb rigidity and pregnancy supination.
Usage: Every time, stir-fry black beans to make smoke, add medicine and a large glass of wine, and when it boils, remove me, open your mouth and fill it twice.
The difference between notopterygium and angelica pubescens
Shennong's Herbal Classic records that "a Notopterygium can live alone". Compendium of Materia Medica records that "Radix Angelicae Pubescentis and Notopterygii Rhizoma are two kinds". Therefore, the two books only have the unique work, and there is no Notopterygium. Although there were notopterygium root and pubescent angelica root in the prescriptions of Jin and Yuan Dynasties, such as Notopterygium root and Gentiana macrophylla decoction, Chinese medicine still insisted that they were the same medicine. It may be because they belong to the same family and genus, and the herbaceous plants on the ground are very similar in morphology. However, Compendium of Materia Medica has recognized that the two drugs are different in appearance and smell, so they are different.
Notopterygium Notopterygium and Radix Angelicae Pubescentis are divided into two medicines from one medicine, which shows that the understanding of traditional Chinese medicine is constantly revised and deepened, and it is constantly developing. Although slow, the understanding attitude is rigorous and scientific.
After Radix Notopterygii and Radix Angelicae Pubescentis were divided into two medicines, there was a saying that Qiang was the only one. Is it only used below the waist? This is also a one-sided view.